Albendazole Tablets

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Therapeutic Indication

Intestinal worm infestations (ascariasis, hookworm, whipworm, pinworm)
Neurocysticercosis (due to Taenia solium)
Hydatid disease (echinococcosis)
Giardiasis in children
Other parasitic infections
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Albendazole

Tablet

Albendazole is a broad-spectrum anthelmintic agent. It works by inhibiting microtubule polymerization in parasites, disrupting glucose uptake, and leading to parasite death. It is widely used in deworming programs and treatment of systemic parasitic infections.

Speciality Parasitology | Infectious Diseases | Pediatrics
Tags Anthelmintic | Deworming | Neurocysticercosis | Hydatid Disease
Strength
  • 400 mg
Packing Size
  • 1 Tablets

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Mechanism

Albendazole binds to parasite β-tubulin, inhibiting microtubule polymerization. This disrupts glucose uptake and depletes glycogen stores, leading to immobilization and death of the parasite.

Pharmacokinetics

  • Absorption: Poor oral absorption; enhanced with fatty meals.
  • Distribution: Widely distributed, including cerebrospinal fluid.
  • Metabolism: Rapid hepatic metabolism to active metabolite albendazole sulfoxide.
  • Elimination: Excreted in urine and bile.
  • Half-life: ~8–12 hours.

Side Effects

  • Nausea, vomiting, abdominal pain
  • Headache, dizziness
  • Elevated liver enzymes
  • Rare: bone marrow suppression

Contraindication

  • Hypersensitivity to albendazole or benzimidazoles
  • Pregnancy (especially first trimester)
  • Severe hepatic impairment

Interaction

  • Cimetidine, praziquantel, dexamethasone: Increase albendazole sulfoxide levels.
  • Hepatotoxic drugs: Additive risk of liver injury.

Warning and Precautions

  • Cimetidine, praziquantel, dexamethasone: Increase albendazole sulfoxide levels.
  • Hepatotoxic drugs: Additive risk of liver injury.

Dosage

As directed by the Physician.